![]() ![]() With increasing COVID-19 vaccination rates in the general population, lymphadenopathy have been frequently observed as an incidental finding in different imaging modalities. ConclusionĪ high incidence of vaccine-induced lymphadenopathy was found in a population of healthy subjects, with nearly complete regression within 4–12 weeks. At follow-up, lymph-node morphology was completely restored in most cases (54/69, 78%) and in no case lymphadenopathy had worsened. SWE showed a soft cortical consistence in all cases (median value 11 Kpa). Vascular signal was mainly found to be increased, localized in both central and peripheral regions. Ultrasound features of vaccine-related lymphadenopathy consisted of absence of fatty hilum, round shape and diffuse or asymmetric cortical thickness (median cortical thickness of 5 mm). Among them, 60 presented vaccine-related side effects, but no statistically significant difference was observed between post-vaccine side effect and lymphadenopathy. Post-vaccine lymphadenopathy were found in 69/89 (78%) participants (37 single and 32 multiple lymphadenopathy). The correlation between lymphadenopathy and vaccine-related side effects was assessed using the Fisher’s exact test. B-mode, color-Doppler assessment, and shear-wave elastography (SWE) evaluation were performed. Participants underwent bilateral axillary, supraclavicular and cervical lymph node stations ultrasound 1–4 weeks after the second dose and then again after 4–12 weeks in those who showed lymphadenopathy at the first ultrasound. Vaccine-related clinical side effects (e.g., fever, fatigue, palpable or painful lymphadenopathy) were recorded. MethodsĨ9 healthy volunteers (median age 30, 76 females) were prospectively enrolled. Purpose of the study was to evaluate the incidence, course and ultrasound imaging features of vaccine-induced lymphadenopathy. ![]() Lymphadenopathy can occur after COVID-19 vaccination and when encountered at ultrasound examinations performed for other reasons might pose a diagnostic challenge. ![]()
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